The tourists were 55 for one at close of play on the rain-disrupted fourth day of the third Test, still 410 runs short of their unlikely victory target of 465.
In-form opener Azhar Ali, who had made 11 not out, and nightwatchman Yasir Shah, unbeaten on three, were at the crease at stumps after debutant Sharjeel Khan had chipped the ball to a midwicket fielder for 40 of spinner Nathan Lyon.
Warner needed just 23 balls to score his half century - two more than the record set by Pakistan skipper Misbah-ul-Haq against the Australians in Abu Dhabi in 2014 - to help the hosts knock off 241 for two before declaring after tea.
Steve Smith (59), Usman Khawaja (79 not out) and Peter Handscomb (40 not out) also poured on the runs after Warner was dismissed for a swashbuckling 55 off 27 deliveries.
“The way the guys batted today, especially Davy of course, to get those runs as quickly as possible and do some pretty unselfish batting, and got us in the position we are in now,” said paceman Josh Hazlewood, who took four for 55.
Pretty
“The wicket’s still pretty good, but I think there’s enough there to create nine more chances, if it’s reverse swing or spin.”
Earlier, after the opening session was washed out for the second day in a row, Younus Khan completed an imperious 175 not out before running out of partners as Pakistan were dismissed for 315, still 223 behind Australia’s first innings 538 for eight.
Australia started the day with the bad news that they had lost opener Matt Renshaw for the rest of the match because of a concussion after he was hit on the helmet while fielding on Thursday.
Khawaja opened in his place but spent his first 40 minutes mostly a spectator as Warner, who on Tuesday become the first batsman to score a century in the opening session of a Test in Australia, again laid waste to the Pakistan bowlers.
Warner slapped a four over midwicket from the first ball he faced and had added 10 more boundaries by the time Wahab Riaz removed his off bail some 42 minutes later.
In one stunning over, the left-hander smashed spinner Yasir for two sixes and two fours from the first four deliveries before adding a single off the fifth for good measure.
Younus’s knock had, by contrast, been a necessarily gritty affair as his team collapsed around him.