Carrie Underwood performs "Softly and Tenderly" during an In Memoriam tribute at the 51st annual CMA Awards at the Bridgestone Arena on Wednesday, Nov. 8, 2017, in Nashville, Tenn. (AP/ PTI Photo)
Other winners at the show included Miranda Lambert (female vocalist of the year), Brothers Osborne (vocal duo of the year) and Jon Pardi (new artist of the year). Campbell and Willie Nelson won musical event of the year for "Funny How Time Slips Away."
Stapleton won male vocalist of the year and album of the year for his sophomore effort, "From A Room: Volume 1."
"I'm always humbled by getting these things," said Stapleton, who thanked his wife Morgane, who is pregnant with twins and was in the audience.
"I want to thank my kids and my kids that are on the way," he added.