Iranian and US negotiators will resume talks on Friday in Rome to resolve a decades-long dispute over Tehran's nuclear ambitions, despite Iran's supreme leader warning that clinching a new deal might be insurmountable amid clashing red lines.
The stakes are high for both sides. President Donald Trump wants to curtail Tehran's potential to produce a nuclear weapon that could trigger a regional nuclear arms race. Iran, for its part, wants to be rid of devastating sanctions on its oil-based economy.
Iranian Foreign Minister Abbas Araqchi and Trump's Middle East envoy Steve Witkoff will hold a fifth round of talks, through Omani mediators, despite both Washington and Tehran taking a tough stance in public over Iran's uranium enrichment.
Although Iran insists the talks are indirect, US officials have said the discussions — including the latest round on May 11 in Oman — have been both "direct and indirect".
Tehran and Washington have both said they prefer diplomacy to settle the standoff, but they remain deeply divided on several red lines that negotiators will have to circumvent to reach a new nuclear deal and avert future military action.
US Secretary of State Marco Rubio said on Tuesday that Washington is working to reach an agreement that would allow Iran to have a civil nuclear energy program but not enrich uranium, while admitting that achieving such a deal "will not be easy."
Supreme Leader Ayatollah Ali Khamenei, who has the last say on state matters, rejected Washington's demands that Tehran stop enriching uranium as "excessive and outrageous", warning that the talks are unlikely to yield results.
Among remaining stumbling blocks is Tehran's refusal to ship all of its highly enriched uranium stockpile abroad or engage in discussions over its ballistic missile programme.
Iran says it is ready to accept some limits on its uranium enrichment but needs watertight guarantees Washington would not renege on a future nuclear accord.
Trump, who has restored a "maximum pressure" campaign on Tehran since February, ditched a 2015 nuclear pact between Iran and six world powers in 2018 during his first term and reimposed sweeping US sanctions that have devastated Iran's economy.
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