Nyon, Switzerland: Former champions Chelsea will face Malmo in the last 32 of the Europa League while Arsenal will lock horns again with BATE Borisov.
The two sides met in the Europa League last season, the Gunners hammering the Belarussian side 6-0 at the Emirates.
Five-time champions Sevilla, currently second in La Liga, face a difficult tie against Lazio, beaten finalists in this competition in 1998, who are fifth in Serie A.
The 2004 champions Valencia will have to overcome Scottish champions Celtic while another Spanish side Villarreal, currently hovering just above the Liga relegation zone, face an Iberian battle when they take on Sporting.
Napoli, demoted to the Europa League after they were knocked out of the Champions League at the group stage, face Zurich.
Portuguese giants Benfica, three times runners-up, tackle Turkish side Galatasaray, Uefa Cup winners in 2000, and Inter Milan, another team who failed to progress to the Champions League knockout stage, will play Rapid Vienna.
The ties will take place on February 12-14 and February 20-21.
Sevilla will face a tough tie against Serie A side Lazio.
Sevilla hit 18 goals on the way to winning their group unbeaten, but Lazio fell into the unseeded pot after scraping through in second place with three wins and three defeats.
Inter Milan, one of the teams who parachuted into the competition after finishing third in their Champions League group, will have their hands full against Rapid Vienna.
“We were disappointed with the Champions League exit but we are ready to have a very good campaign in the Europa League now,” Inter vice-president Javier Zanetti said.
Elsewhere, Eintracht Frankfurt against Shakhtar Donetsk and Zenit St Petersburg against play Fenerbahce.