Iran has launched about 100 drones towards Israeli territory in retaliation to the strike on its nuclear facilities.
Israeli military spokesman Brigadier General Effie Defrin said they are working to intercept the drones.
Israel launched widescale strikes against Iran on Friday, saying it targeted nuclear facilities, ballistic missile factories and military commanders during the start of a prolonged operation to prevent Tehran from building an atomic weapon.
Iranian media and witnesses reported explosions including at the country's main uranium enrichment facility at Natanz, while Israel declared a state of emergency in anticipation of retaliatory missile and drone strikes.
The International Atomic Energy Agency said on Friday there was no increase in radiation levels at the Natanz nuclear site, citing information given to them by Iranian authorities.
Iran's elite Revolutionary Guards corps said its top commander, Hossein Salami, was killed and state media reported the unit's headquarters in Tehran had been hit. Several children had been killed in a strike on a residential area in the capital, it said.