The US said it had completed an eighth straight night of attacks against Iran after earlier announcing that two US military personnel were killed in Jordan and another was missing following an Iranian attack.
The US and Iran have intensified attacks since an interim ceasefire deal signed a month ago fell apart last week, raising the possibility of a return to all-out war.
US Central Command said in a statement that the airstrikes began at 6 pm ET (Bahrain time 2am) on Saturday, at President Donald Trump's direction.
"The strikes are designed to further degrade Iran's ability to threaten commercial shipping in the Strait of Hormuz and swiftly punish Islamic Revolutionary Guard Corps forces who launched attacks against American service members in Jordan last night," it said.
Central Command later said it had completed its wave of attacks, hitting Iranian military coastal surveillance and air defence facilities.
Central Command said the two deaths occurred on Friday and that a third US service member was missing in action. The announcement brought the number of US service members killed since the war began to 16, while more than 420 have been wounded.
US Defence Secretary Pete Hegseth posted on X: "Their sacrifice only stiffens our resolve."