England manager Gareth Southgate kept faith with centre back Harry Maguire, including him in a back four to play Iran, who will start with star forward Sardar Azmoun on the bench for the World Cup Group B encounter on Monday.
Maguire, who has been out of favour at club side Manchester United this season, starts alongside John Stones in a back four, with Southgate opting against his usual three-man backline for the encounter at Khalifa International Stadium.
England are without midfielder James Maddison, who is nursing a knee injury, while Bukayo Saka and Raheem Sterling will play in a three-man frontline with captain Harry Kane.
Azmoun has not played since injuring his calf at the start of October.
England: Jordan Pickford, John Stones, Harry Maguire, Kieran Trippier, Declan Rice, Jude Bellingham, Mason Mount, Luke Shaw, Bukayo Saka, Harry Kane, Raheem Sterling
Iran: Alireza Beiranvand, Sadegh Moharrami, Ehsan Hajsafi, Milad Mohammadi, Alireza Jahanbakhsh, Morteza Pouraliganji, Mehdi Taremi, Rouzbeh Cheshmi, Ali Karimi, Majid Hosseini, Ahmad Nourollahi